the miracle of the hormones

The SRP Structure: The Guide in the Cell


Imagine that you are visiting a country for a very short time and that you do not know the language spoken in that country. In this situation, you will urgently need the services of a guide. Similarly, SRP acts as a guide for newly produced proteins.

Imagine that you are making a very short visit to a foreign country whose language you do not know. In this situation you urgently need a guide that will both allow you to communicate with the local people and help you with your visit without getting lost.

Similarly, there is a particle in cells that acts as a guide for newly formed proteins. This guide is the SRP mentioned above whose complex structure is composed of protein and RNS molecules. On the exterior it resembles a bowling pin only 0.000000024 meter in size.

SRP understands the language both of proteins and of the receptor-entrance channel complex on the membrane of the endoplasmic reticulum. The complicated structure of this guide is not yet completely understood; scientists suspect that the RNA molecule in the SRP has an important role, but they have not been able to understand the function of this molecule yet. Moreover, the intricacies of the relation between the SRP guide and the receptor-entrance channel are still unknown.56

A professor of molecular biochemistry known for his research in this field, J.A. Doudna, stated that the relation formed between the protein and the RNA, which is one of the components of the SRP, is a "fascinating network"57 and "example of true molecular collusion."58 Indeed, this structure is truly amazing because RNA and protein have been created in such a way as to work in flawless harmony with each other, and have been brought together for the performance of a special function. There is no difference in proposing that this design came to be by chance and maintaining that a cell phone came to be by an alliance made by atoms and molecules among themselves. The crystal structure of this protein that became understood only in the year 2000 is, without doubt, a product of superior design. It is an eternal sign of the power and knowledge of God.

Communication and Transportation in the Nucleus

It is known that a cell's nucleus contains a data bank (the DNA molecule) in which all physical characteristics are encoded in their smallest details. Many operations within a cell are carried on with reference to the information in the DNA. Therefore, between the nucleus and the cytoplasm and the various organelles there is heavy protein traffic at every moment. This traffic and communication is organized to respond to the needs of the cell.


The entrance-exit complexes on the membrane of a cell's nucleus. In the lower section of the illustration you can clearly see the channel opening through which RNA and DNA molecules can pass.

The nucleus of the cell is different from other organelles; it is surrounded by a double membrane. On this membrane are located entrance-exit complexes (Nuclear Pore Complexes) used by proteins. These are entrance-exit complexes and not entrance-exit channels because of their structure. Thanks to this special system, comparatively large groups of molecules like RNA and DNA can pass through the nuclear membrane so that the delicate structure of the protein and the molecules are not damaged. When the entrance/exit complex is completely open, they are ten times bigger than the channels in other organelles. Research has shown that there are ten entrances and ten exits every second through each entrance/exit complex.59 The entrance and exit of a protein into and out of the nucleus of a cell is completed under the guidance of "karyopherin." This special guide is of various types that bind to the protein and direct it to the entrance/exit complex. Moreover, different proteins and enzymes also have a function in the transfer operation.

This extraordinarily integrated and complex protein transfer system has once again left evolutionist scientists without recourse; Professor GŁnter Blobel confessed that "the detailed mechanisms for transport across the NPC[Nuclear Pore Complex] are still unknown."60 Take, for example, the karyopherin that establishes communication and directs the passage; the scientific articles written on the functions of this one particle fill thousands of pages. The extraordinary design of one single particle is a clear demonstration of creation. If we notice that several guide particles exist with different characteristics and structures, we better understand that God's eternal knowledge encompasses all things.

Unique Systems Whose Secrets Have Not Yet Been Discovered


Günter Blobel

Every day scientific research sheds light on the various operations of the cell's "zip code" system. A short time ago, it was understood that a system similar to this existed in the immune system and antibodies are produced by this method. Moreover, it is known that a group of special molecules exist that let blood cells leave the circulatory system and direct them to the relevant tissues.

What we know about the incomparable systems in the cells is quite small compared to what we do not know. The Nobel Prize is usually shared by a number of scientists, but in 1999, only Gunter Blobel took the award for his discovery of the zip code system in cells. In an interview done after he received the award, Professor Blobel said:

We are at the level now that we understand many of the basic mechanisms of protein traffic within the cell but we haven't understood them all yet. We are working, for instance, on traffic between the nucleus and the cytoplasm, and we are far from understanding how this traffic is regulated and how it works.61

The truth is evident. No matter where we go, every point in the depths of space, of the sea, of the forest or in the deep recesses of our bodies is redolent with signs of God's knowledge, art and power. People were unaware in past centuries of the wonders of creation contained in cells; but each one of them captures the imagination today. Every new development in cell biology documents the fact that the claims of evolutionists are deceitful nonsense. At the same time, they show once again that the wonderful order in cells was created by God's single command; "Be" and that they are under His control at each moment. Every detail determined relative to a cell is an occasion for us to exalt the glory and power of our Lord, Almighty God.

His command when He desires a thing is just to say to it, "Be!" and it is. Glory be to Him Who has the Dominion of all things in His Hand. To Him you will be returned. (Qur'an, 36: 82-83)

56 R.T. Batey, R.P. Rambo, L. Lucast, B. Rha, J.A. Doudna, "Crystal structure of the ribonucleoprotein core of the signal recognition particle," Science, 18 February 2000, vol. 287, no. 5456, pp. 1232-1239
57 Jennifer A. Doudna, "RNA Catalysis, RNA Processing, and Translation," 2000, http://www.hhmi.org/research/investigators/doudna.html
58 YALE News Release, "Yale Researcher Identifies Structure of Molecular Zip Code Reader," 2000, http:// www.yale.edu/opa/newsr/00-02-17-01.all.html
59 The Rockefeller University News, "Rockefeller University Cell Biologist, Gunter Blobel, Wins 1999 Nobel Prize in Physiology or Medicine," 1999, http://www.rockefeller.edu/pubinfo/blobel.nr.html
60 E. Conti, M. Uy, L. Leighton, G. Blobel, J. Kuriyan, "Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin alpha," Cell, July 1998, vol. 94, pp. 193-204
61 Online NewsHour, "Nobel Prize for Medicine," 11 October 1999, http://www.pbs.org/newshour/nobel_1999/blobel.html