The Messenger in Sperm
The nitric oxide synthase (NOS) enzyme in the
sperm begins to produce NO a few seconds before
fertilization. When union occurs, the NO messenger
molecules in the sperm disperse within the egg.
Thirty seconds later, the calcium in the egg is
activated and the first cells divide and the multiplying
mechanism goes into action.
Another very important function performed on our behalf
by this molecule occurs in the first moment of our lives.
First, we must notice when we say "the first moment
of our lives," we do not mean the moment we were born.
The first moment of our lives is the first moment of
the one cell that formed us, when the sperm united with
When the sperm and the egg meet, a
number of incredibly complex chemical operations begin,
and as a result, an embryo is formed. But, among the
many details that are still unknown, there is an important
point that can be summarized in the words of Professor
David Epel who said, "Since the turn of the century,
people have wondered exactly how sperm-egg contact initiates
The research carried out to find the answer to this
question has shown that the messenger carried by NO
initiates the wonderful process in the mother's womb.
Inside the sperm there is an enzyme called Nitric Oxide
Synthase (NOS). This enzyme begins to produce NO a few
seconds before fertilization with perfect timing. When
union occurs, the nitric oxide molecules in the sperm
are dispersed within the egg; thirty seconds later,
the calcium in the egg is activated and, the multiplication
mechanism in the first cell goes into operation. The
wonderful organization within this first cell is not
yet fully understood. It is interesting for us to notice
that, if there were an insufficiency in the nitric oxide
molecule, communication between the sperm and the egg
would not be established. Science came to understand
this fact only in the year 2000; this shows us again
that nitric oxide was created by God and appointed by
Him to perform its functions.
Face to Face With Bacteria and Viruses
Earlier we mentioned that, although nitric oxide carries
vital messages, it is also a poisonous molecule. So,
the role of NO in the immune system is related to its
poisonous qualities. This molecule is secreted by macrophages,
which are important in the body's immune system. Recall
that macrophages are microorganisms 0.01 of a millimeter
in size. By a process called phagocytosis, they remove
(swallow) bacteria and molecules, which are dangerous
for our bodies. When a macrophage meets germs or bacteria
that cause sickness, it surrounds them; afterwards,
the bacteria that are embraced on every side by the
macrophages are subjected to a bombardment of nitric
oxide. In this way, nitric oxide molecules start a reaction
to destroy the bacteria. Certainly, the cooperation
between nitric oxide and macrophages is one of the countless
proofs of the harmonious creation.
When parasites and bacteria are in their division
(multiplying) stages they form a relationship
with macrophages, ensuring that they produce NOs.
(a) This enzyme produces nitric oxide from oxygen
and argine, which adheres to its own iron atom.
The NO that is produced blocks the multiplication
of parasites. (b)
The NO molecules have another interesting role in the
immune system. Research has shown that NO renders the
"protease" enzyme found in some viruses ineffective.
This enzyme breaks down big proteins into small parts
that are used in the production of new viruses. NO puts
this enzyme out of operation, preventing the virus from
Tiny molecules find other molecules in a body that
they have never before encountered and know very well
how to neutralize their effects. In this way, people
can be rescued from great dangers that they were not
even aware of. It is very clear that all this order
and connection among molecules cannot be the result
of chance. God, the Lord of the universe, has given
the NO molecules their function and created them with
their special qualities.
Research in this field continues, and it is thought
that, in the near future, scientists will be able to
use nitric oxide in the fight against cancer. Each new
bit of information that comes to light will show once
again that this molecule is a product of extraordinary
Every day, the nitric oxide molecule is subject of
new research, and the results of this research amaze
even scientists. What is known at this point is that
this messenger molecule is produced in various cells
throughout our whole body, and that it has important
functions in many bodily operations. In order to understand
how utterly astonishing the activities of this molecule
are, put yourself for a moment in the place of NO and
imagine that you are undertaking its duties.
1. First, imagine that you must take
over the role of this molecule in adjusting the blood
vessels. In order to do this successfully, you must
first know the circulatory system and its components-heart,
blood and blood vessels-very well.
2. In the course of various daily
activities such as sleeping, eating and playing sports,
you will need to communicate messages about the adjustment
of blood pressure to the relevant organs. In doing this,
you cannot overlook anything or make the slightest error.
Otherwise, the blood pressure would fall lower or rise
higher than normal, opening the way for a stroke, shock,
heart attack and other conditions that could result
in death. Moreover, remember that the veins, arteries,
and capillaries in our bodies have a total length of
more than 100 thousand kilometers. Given this, you can
safely guess that you could not possibly perform this
3. It is known that NO is used as
a messenger in our brain during the process of learning.
These operations are so complex that a large part of
them is still not understood. Therefore, the concerted
efforts of the whole scientific world could not possibly
accomplish this messenger function, let alone you, a
4. Do not forget the part played by
nitric oxide in the successful fight by the immune system
against viruses and bacteria.
5. Moreover, in this section we have
not touched on the role of the messenger in the functioning
of the lungs, liver, kidneys, stomach and the reproductive
system. When you take the place of NO in a human body,
you must understand the language of all these organs;
you must be an expert in them all. Of course, this is
not enough because there is nothing that can be compared
to the human body with all its organs working in harmony
and all its trillions of cells performing incredibly
6. Finally, you must keep in mind
that, if this messenger is not used in the right proportion,
with the right timing and in just the right place, harmful
and dangerous results could occur. This could be compared
to a person who has done very complicated processes
with dynamite or some other explosive substance every
moment for 60-70 years and who has not miscalculated
by even one second in the complex operations he has
No matter how much of an expert you are, you must confess
that you would not be able to do what this molecule
does, even with the help of the most advanced computers
Certainly, the nitric oxide messenger molecule has
been created by God Who has "created
everything and determined it most exactly…" (Qur'an,
25: 2) Although this molecule has no sense organs,
intelligence, consciousness, education or technical
training, the fact that it can regulate the operations
of cells, make and carry out on its own initiative delicate
and necessary decisions relative to the human body,
comes from God's superior and incomparable design.
All this information has been obtained during the last
decade of the twentieth century as a result of intense
research by scientists who are considered authorities
in this field. Certainly, all the things unknown about
NO cannot be brought to light just by the work of individual
researchers; there are other factors that must be considered.
States and international foundations have spent enormous
amounts of money on scientific work in this field and
have established laboratories with tools that are the
product of the latest technology.
Certainly, the fact that the wonders of creation contained
in this messenger molecule have been discovered only
after so much work and effort is another demonstration
of the superior knowledge of God.
81 D. Epel, "Scientists discover
key ingredient in sexual reproduction," Stanford
University News Service, 2000, http://www.stanford.edu/dept/news/